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SARS-CoV-2 parental vaccination and risk of multisystem inflammatory syndrome in children: a single-center
Raffaele Falsaperla1,2,3, Vincenzo Sortino2, Ausilia Desiree Collotta2,4
1Neonatal Intensive Care Unit, San Marco Hospital, University Hospital Policlinico "G. Rodolico-San Marco", Catania, Italy.
Insights
Parental vaccination against SARS-CoV-2 may protect children from developing multisystem inflammatory syndrome in children (MIS-C). Children with both parents vaccinated had an 83% lower risk of MIS-C.
Area of Science:
- Pediatrics
- Infectious Diseases
- Immunology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) typically causes mild illness in children.
- Multisystem inflammatory syndrome in children (MIS-C) is the most severe consequence of SARS-CoV-2 infection in pediatric populations.
- Data on the protective effect of parental vaccination on MIS-C development in children are lacking.
Purpose of the Study:
- To investigate the relationship between parental SARS-CoV-2 vaccination and the occurrence of MIS-C in children.
- To determine the protective value of parental vaccination against MIS-C in pediatric patients.
Main Methods:
- Retrospective, single-center study.
- Inclusion of 124 pediatric patients (1 month to 18 years) admitted between April 2020 and March 2022.
- Analysis of MIS-C development in relation to parental vaccination status.
Main Results:
- Parental vaccination showed a negative correlation with MIS-C development.
- 4% of patients with both parents vaccinated developed MIS-C, compared to 20% in patients with no parental vaccination.
- A significant reduction in MIS-C probability was observed with parental vaccination.
Conclusions:
- Parental vaccination may be a significant factor in mitigating the risk of MIS-C in children.
- If both parents are vaccinated, the probability of a child developing MIS-C is reduced by 83%.
Purpose:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually causes a mild disease in children and the most serious consequence is multisystem inflammatory syndrome in children (MIS-C). Currently, there are no data about the protective role of vaccination performed by parents on children regarding the development of MIS-C. The aim of our study is to establish whether parental vaccination is related to MIS-C and the protective value of SARS-CoV-2 vaccination performed by parents against the occurrence of MIS-C in their children.
Materials And Methods:
Our retrospective single center study included 124 patients aged 1 month to 18 years admitted to emergency department from April 2020 to March 2022 for coronavirus disease 2019 disease.
Results:
Parental vaccination was negatively correlated with the development of MIS-C: 4% of patients with both parents vaccinated developed MIS-C, while patients with no parent vaccinated to have developed MIS-C were 20%.
Conclusion:
Parental vaccination could be an important factor influencing the course of the disease and reduces the probability that a child would develop MIS-C by 83% if both parents vaccinated.
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