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Method to Measure Tone of Axial and Proximal Muscle

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An Algorithm for Automated Measurement of Kinetic Tremor Magnitude Using Digital Spiral Drawings.

Katherine Longardner¹, Qian Shen¹, Bin Tang²

¹Department of Neurosciences, University of California San Diego, San Diego, CA, USA.

Digital Biomarkers

|August 15, 2024

Summary

This summary is machine-generated.

A new algorithm accurately measures essential tremor amplitude using digital spiral drawings. This objective method shows promise for clinical trials, offering a reliable alternative to subjective rating scales.

Keywords:

Algorithms Digital biomarker Digital health technology Digital outcome measure Objective data Objective endpoint Spiral drawing Tremor

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Area of Science:

Neurology
Biomedical Engineering
Medical Technology

Background:

Essential tremor (ET) is a common movement disorder.
Current clinical rating scales for ET severity are rater-dependent and lack precision.
Objective tremor amplitude measures often yield unitless, difficult-to-interpret results.

Purpose of the Study:

To develop and validate a novel algorithm for measuring kinetic tremor amplitude using digital spiral drawings.
To establish the reliability and clinical utility of this technology-based objective measure for ET.

Main Methods:

Archimedes spiral drawings were recorded on a digitizing tablet from 7 participants in a cannabinoid efficacy trial.
A novel algorithm was developed to calculate mean and maximum tremor amplitude from spiral tracings.
Digital measurements were compared to manual measures for sensor reliability, assessed for test-retest reliability, and correlated with TETRAS scores.

Main Results:

The algorithm demonstrated high correlation with manual tremor amplitude spot measures.
Excellent test-retest reliability was observed for the digital tremor amplitude measurements.
High correlation was found between digital measures and human ratings of TETRAS scores for "slight tremor" or worse.

Conclusions:

This digital algorithm provides a simple, clinically relevant, and objective measure of kinetic tremor amplitude.
The method shows significant promise as a future endpoint in essential tremor clinical trials.
Automated assessment of tremor amplitude offers enhanced precision and sensitivity compared to traditional methods.