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Related Concept Videos

Cardiovascular System Abnormal Findings II: Auscultation01:25

Cardiovascular System Abnormal Findings II: Auscultation

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Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
114
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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Related Experiment Video

Updated: Jun 16, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

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Characterizing left ventricular systolic dysfunction in sickle cell disease: three contrasting case reports.

George Katis1, Sridhar Srinivasan1, Perla Eleftheriou1

  • 1University College Hospital, 235 Euston Road, London NW12BU, UK.

European Heart Journal. Case Reports
|August 15, 2024
PubMed
Summary

Left ventricular systolic dysfunction (LVSD) in sickle cell disease (SCD) has varied causes, including iron overload, non-ischemic dilated cardiomyopathy, and ischemic cardiomyopathy. Understanding these distinct mechanisms is crucial for effective patient treatment.

Area of Science:

  • Cardiology
  • Hematology
  • Genetics

Background:

  • Left ventricular systolic dysfunction (LVSD) is a rare but serious complication of sickle cell disease (SCD).
Keywords:
Cardiac MRICase reportHeart failureLeft ventricular systolic dysfunctionSickle cell disease

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  • The underlying causes of LVSD in SCD are not well understood.
  • This study examines three distinct cases of LVSD in SCD patients.