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Correlation between initial alkaline phosphatase levels and overall survival in newly diagnosed multiple myeloma patients

  • 0Department of Hematology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Translational Cancer Research +

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August 15, 2024

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August 15, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Alkaline phosphatase (ALP) levels in multiple myeloma (MM) patients correlate with survival outcomes. An ALP range of 70 to <120 U/L is associated with better prognosis in newly diagnosed MM patients.

Area Of Science

  • Hematology
  • Oncology
  • Biochemistry

Background

  • Alkaline phosphatase (ALP) is a marker that may reflect multiple myeloma (MM) patient status.
  • The precise relationship between ALP and MM prognosis remains unclear.
  • This study investigates the association between initial ALP levels and overall survival in newly diagnosed MM patients.

Purpose Of The Study

  • To determine the association between initial alkaline phosphatase (ALP) levels and overall survival in newly diagnosed multiple myeloma (MM) patients.
  • To identify optimal ALP cut-off values for prognostic stratification.
  • To explore the correlation of ALP with other clinical and biochemical markers in MM.

Main Methods

  • Retrospective analysis of clinical data from 202 newly diagnosed MM patients.
  • Patients categorized into three groups based on ALP levels: <70 U/L, 70 to <120 U/L, and ≥120 U/L.
  • COX regression analysis used to identify independent risk factors for survival.

Main Results

  • Significant differences in survival, liver function, and bone disease markers were observed across ALP groups (P<0.05).
  • Median survival was 25, 52, and 31 months for ALP groups <70, 70-<120, and ≥120 U/L, respectively.
  • Patients with ALP 70 to <120 U/L showed significantly higher 3-year survival (P=0.006).
  • Independent prognostic factors included age, ISS stage, AST, β2-microglobulin, ALP grade, and severe bone disease.

Conclusions

  • Initial alkaline phosphatase (ALP) levels are significantly correlated with the prognosis of multiple myeloma (MM) patients.
  • An ALP range of 70 to <120 U/L is associated with a better survival expectation in newly diagnosed MM.
  • ALP stratification can aid in risk assessment and treatment planning for MM patients.

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