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Age- and Sex-Specific Analysis of Stroke Hospitalization Rates, Risk Factors, and Outcomes From German Nationwide
Dearbhla M Kelly1, Christiane Engelbertz2, Peter M Rothwell1
1Wolfson Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, United Kingdom (D.M.K., P.M.R.).
Stroke
|August 15, 2024
Summary
Men have higher stroke admission rates, but women face increased in-hospital mortality for both ischemic and hemorrhagic stroke. Understanding these sex differences is crucial for developing targeted stroke care strategies.
Area of Science:
- Neurology
- Public Health
- Epidemiology
Background:
- Sex and age significantly influence stroke risk, treatment, and outcomes.
- Previous studies faced limitations due to confounders and selection bias.
- German nationwide data offer a robust analysis of stroke trends.
Purpose of the Study:
- To quantify age- and sex-specific differences in stroke.
- To analyze trends in admission rates, risk factors, and treatments for ischemic and hemorrhagic stroke.
- To investigate in-hospital mortality disparities between sexes.
Main Methods:
- Analysis of nationwide German administrative data (2010-2020).
- Inclusion of all acute stroke hospitalizations (ICD codes I60-64) for patients aged 15+.
- Stratification by sex, stroke subtype, and age group.
Main Results:
- Men exhibited higher admission rates for both ischemic and hemorrhagic stroke.
- Ischemic stroke admissions peaked in 2016/2017 and declined thereafter.
- Female sex was linked to higher in-hospital mortality for both stroke types.
Conclusions:
- Sex-specific disparities in stroke hospitalization and mortality persist.
- Understanding these differences is key to sex-stratified stroke care.
- Further research into the mechanisms behind these disparities is warranted.
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