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RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer

  • 0Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Elife +

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August 15, 2024

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August 15, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Regulator of G protein-signaling 10 (RGS10) acts as a tumor suppressor in breast cancer. Lower RGS10 levels correlate with increased metastasis and poorer patient prognosis, highlighting its potential as a therapeutic target.

Area Of Science

  • Oncology
  • Molecular Biology
  • Cancer Research

Background

  • Distant metastasis significantly contributes to breast cancer mortality.
  • Epithelial-mesenchymal transition (EMT) is a key process driving cancer metastasis.
  • Regulator of G protein-signaling (RGS) proteins are implicated in modulating metastasis across various cancers.

Purpose Of The Study

  • To investigate the role of RGS10 in epithelial-mesenchymal transition (EMT) and metastasis in breast cancer.
  • To determine the prognostic significance of RGS10 protein levels in breast cancer patients.

Main Methods

  • Comparative analysis of RGS10 protein levels in breast cancer tissues versus normal tissues.
  • Assessment of RGS10 expression in breast cancer cell lines with varying aggressiveness (MDA-MB-231, MCF7, SKBR3).
  • Functional studies involving RGS10 gene silencing in SKBR3 cells to evaluate effects on EMT, migration, and invasion.

Main Results

  • RGS10 protein levels were significantly reduced in breast cancer tissues compared to normal tissues.
  • Lower RGS10 expression correlated with a worse prognosis in breast cancer patients.
  • RGS10 deficiency promoted EMT, migration, and invasion in breast cancer cells, mediated by lipocalin-2 and MIR539-5p.

Conclusions

  • RGS10 functions as a tumor suppressor in breast cancer.
  • RGS10 serves as a valuable prognostic biomarker for breast cancer.
  • RGS10 represents a potential therapeutic target for mitigating breast cancer metastasis.

Keywords:

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