Related Experiment Video
Updated: Jun 16, 2025
07:13
Orienteering as a Tool for Cognitive Research: An Implementation Guide
Published on: November 29, 2024
719
Exercise-produced irisin effects on brain-related pathological conditions.
Ricardo Augusto Leoni De Sousa1,2,3
1Physical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Diamantina, MG, Brazil. ricardoaugustoleonidesousa@gmail.com.
Metabolic Brain Disease
|August 15, 2024
Summary
Exercise boosts irisin, a protein linked to improved insulin sensitivity and reduced inflammation. This peptide shows promise for treating brain conditions like Alzheimer's and Parkinson's disease.
Area of Science:
- Exercise Physiology
- Molecular Biology
- Neuroscience
Background:
- Exercise stimulates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) expression.
- PGC-1α promotes the production and cleavage of fibronectin type III domain containing 5 (FNDC5) protein into irisin, primarily in skeletal muscle.
Purpose of the Study:
- To review the role of exercise-induced irisin in conditions including Alzheimer's disease (AD), Parkinson's disease (PD), epilepsy, type 2 diabetes, and obesity.
- To explore irisin as a potential therapeutic target for brain-related pathologies.
Main Methods:
- Literature review of studies on exercise, irisin, and associated diseases.
- Analysis of molecular pathways affected by irisin, including insulin receptor phosphorylation and the PI3K pathway.
Main Results:
- Various exercise types (resistance, aerobic, HIIT) increase irisin levels.
- Irisin enhances insulin signaling, combats insulin resistance, inflammation, and cognitive decline.
Conclusions:
- Exercise-induced irisin is a key mediator in improving metabolic and cognitive health.
- Irisin presents a promising therapeutic avenue for neurodegenerative diseases, metabolic disorders, and obesity.
Related Concept Videos
01:20Exercise and Cardiovascular Response
755
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
755
01:27Psychoneuroimmunology: Cardiovascular Disease
28
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
28
01:17Exercise and Cardiac Output
950
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
950
01:17Irritable Bowel Syndrome I: Introduction
264
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
264
01:14Brain Imaging
219
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
219
01:25Stress Prevention and Stress Management Techniques III
55
Regular exercise and meditation serve as essential tools in managing stress and promoting physical and mental well-being.
The Role of Exercise in Stress Management
Regular physical activity is essential for reducing stress and promoting cardiovascular health. Exercise strengthens the heart, enhances blood flow, keeps blood vessels flexible, and helps lower blood pressure, all of which reduce the body's stress response. Research shows that adults who exercise regularly have nearly half the...
The Role of Exercise in Stress Management
Regular physical activity is essential for reducing stress and promoting cardiovascular health. Exercise strengthens the heart, enhances blood flow, keeps blood vessels flexible, and helps lower blood pressure, all of which reduce the body's stress response. Research shows that adults who exercise regularly have nearly half the...
55