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[Gender-specific differences in the development of colorectal cancer in Lynch syndrome patients-A systematic review]
Jonas Dohmen1,2, Nils Sommer3,4, Katrin van Beekum5,4
1Klinik und Poliklinik für Allgemein‑, Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland. Jonas.Dohmen@ukbonn.de.
Background:
Lynch syndrome (LS) is the most frequent hereditary tumor syndrome and is associated with an increased risk of colorectal cancer (CRC). While gene-specific and age-specific differences are considered in patient surveillance, gender-specific risks in the development of CRC have been reported in many studies but are not consistently documented.
Objective:
This systematic review aims to investigate gender-specific differences in CRC development among LS patients.
Material And Methods:
A systematic literature search following PRISMA 2020 guidelines was conducted in the PubMed, Ovid, The Cochrane Library and Web of Science databases. A total of 688 studies were screened, and 41 met the inclusion criteria.
Results:
Men have a higher risk of CRC and develop CRC earlier compared to women.
Conclusion:
These findings indicate gender-specific differences in the risk of CRC among LS patients, although they do not currently justify separate surveillance strategies.
