[Multiple trichoepitheliomas with genital and paragenital localization. Ultrastructural study]

Area of Science:

• Dermatology
• Oncology
• Histopathology

Background:

• Trichoepithelioma papulosum multiplex is a rare benign adnexal tumor.
• Understanding its clinical and ultrastructural characteristics is crucial for differential diagnosis.

Observation:

• A 35-year-old woman presented with multiple trichoepithelioma papulosum multiplex lesions.
• Genital and paragenital locations of these lesions were observed for the first time.
• Islands of basaloid cells and horny cysts were examined using electron microscopy.

Findings:

• Electron microscopy revealed distinct ultrastructural features differentiating trichoepithelioma papulosum multiplex from basal cell epithelioma.
• The study provides detailed ultrastructural analysis of the basaloid cell islands and horny cysts.

Implications:

• This case expands the known clinical presentation of trichoepithelioma papulosum multiplex.
• The ultrastructural findings aid in distinguishing this benign tumor from malignant basal cell epithelioma.
• Highlights the importance of detailed histopathological examination for accurate diagnosis.