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Association between blood lead, cadmium, selenium levels and hyperlipidemia: A population-based study
Yangping Zhuang1,2,3, Yu Wang1,2,3, Peifen Sun1,2,3
1Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Higher blood lead (Pb), cadmium (Cd), and selenium (Se) levels are associated with an increased risk of hyperlipidemia. This epidemiological study investigated the link between these metals and lipid biomarkers in a large population sample.
Area of Science:
- Environmental Health
- Epidemiology
- Toxicology
Background:
- Limited epidemiological data exists on blood metal levels and hyperlipidemia.
- Previous studies on blood lead (Pb), cadmium (Cd), and selenium (Se) and lipid biomarkers have yielded conflicting results.
Purpose of the Study:
- To investigate the association between blood levels of lead (Pb), cadmium (Cd), and selenium (Se) and the risk of hyperlipidemia.
- To explore potential nonlinear relationships and threshold effects.
Main Methods:
- Utilized data from the National Health and Nutrition Examination Survey (NHANES).
- Employed multivariate logistic regression and subgroup analyses to assess the relationship between blood metal levels and hyperlipidemia.
- Applied smoothed curve fitting and threshold effect analysis to characterize nonlinear relationships.
Main Results:
- Included 5429 participants (mean age 53.70 ± 16.63 years; 47.1% male).
- Found a positive correlation between blood lead (Pb) and selenium (Se) levels and hyperlipidemia (Pb OR: 2.12, 95% CI: 1.56-2.88; Se OR: 1.84, 95% CI: 1.38-2.45).
- Smooth curve fitting confirmed positive correlations between blood Pb, Cd, and Se levels and hyperlipidemia risk, independent of common confounders.
Conclusions:
- Elevated blood levels of lead (Pb), cadmium (Cd), and selenium (Se) are associated with an increased risk of hyperlipidemia.
- These findings highlight the potential role of environmental metals in the development of hyperlipidemia.
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