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The quality-adjusted life-years loss due to serogroup B invasive meningococcal disease in Spain

Andrea García1, Laura A Vallejo-Aparicio1, Najida Begum2

  • 1GSK, Tres Cantos, Spain.

Vaccine
|August 15, 2024
PubMed
Abstract

Insights

The humanistic burden of serogroup B invasive meningococcal disease (MenB-IMD) in Spain is substantial, primarily driven by long-term sequelae in patients and their families. This study quantifies the significant quality-adjusted life-year (QALY) loss associated with MenB-IMD.

Area of Science:

  • Public Health
  • Epidemiology
  • Health Economics

Background:

  • Limited evidence exists on the humanistic burden of serogroup B invasive meningococcal disease (MenB-IMD) in Spain.
  • This study addresses the paucity of data by estimating the societal impact of MenB-IMD.

Purpose of the Study:

  • To estimate the total quality-adjusted life-year (QALY) loss due to MenB-IMD in Spain from a societal perspective.
  • To quantify the direct and indirect humanistic burden of MenB-IMD on patients and their families/caregivers.

Main Methods:

  • An incidence-based Excel tool adapted for the Spanish setting was utilized.
  • QALY losses were estimated over a lifetime horizon, incorporating direct and indirect impacts.
  • Discount rates and sensitivity analyses were applied to assess uncertainty.

Main Results:

  • A hypothetical cohort of 142 MenB-IMD cases resulted in a total discounted QALY loss of 572.44 (4.03/case).
  • Direct loss (patients) accounted for 81.2% and indirect loss (families/caregivers) for 18.8% of the total.
  • Sequelae significantly drove QALY loss (60.5% for patients, 84.6% for caregivers); children under 5 years old represented 47.8% of the total loss.

Conclusions:

  • The humanistic burden of MenB-IMD is substantial, largely influenced by long-term sequelae.
  • Both patients and their relatives/caregivers experience significant quality-of-life impacts.
  • Findings highlight the importance of addressing the sequelae of MenB-IMD to mitigate societal burden.
Keywords:
Direct costsHumanistic burdenIndirect costsInvasive meningococcal diseaseMenBQALY lossSpainSpillover effect

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