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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Updated: May 5, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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Light-Driven Microrobots for Targeted Drug Delivery.

Qilong Cheng1, Xingqi Lu1, Yunhao Tai1

  • 1School of Biomedical Engineering, Anhui Medical University, Hefei 230032, China.

ACS Biomaterials Science & Engineering
|August 15, 2024
PubMed
Summary
This summary is machine-generated.

Light-driven microrobots offer precise, non-contact control for biomedical applications like drug targeting. This review explores their mechanisms, designs, and future potential in medicine.

Keywords:
based on biologyin vivo imagingmicrorobotmicrorobot swarmsmultiphysics fieldphotochemicalphotothermaltargeted drug delivery

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Robotics

Background:

  • Light-driven microrobots are emerging tools for precise manipulation in biomedical fields.
  • Light field control offers advantages like non-contact operation, precise localization, and biocompatibility.

Purpose of the Study:

  • To provide an overview of light-driven microrobots for drug targeting applications.
  • To explore novel ideas for microrobot manipulation using light fields.

Main Methods:

  • Categorization of driving mechanisms (photothermal, photochemical, biological) and materials.
  • Summarization of microrobot designs and control strategies across multiple physical fields.
  • Review of current applications in drug targeting and bioimaging.

Main Results:

  • Light fields enable precise control of microrobots through light-induced forces or deformations.
  • Integration with drug release technology facilitates targeted drug delivery.
  • Diverse designs and control strategies are being developed for various applications.

Conclusions:

  • Light-driven microrobots show significant promise for targeted drug delivery and bioimaging.
  • Further research into driving mechanisms, materials, and control strategies is crucial.
  • These microrobots represent a promising future for advanced biomedical manipulation.