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Updated: Jun 16, 2025

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy

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Published on: July 20, 2022

Weight-specific normal liver stiffness values in children.

Paul Knebelmann¹, Antoine Martin-Champetier², Anderson Loundou³

¹Department of Pediatric and Prenatal Radiology, Hôpital Timone Enfants, APHM, 264 Rue Saint Pierre, 13005, Marseille, France. paul.knebelmann@gmail.com.

Pediatric Radiology

|August 15, 2024

Summary

This summary is machine-generated.

Pediatric liver stiffness, measured by two-dimensional shear wave elastography, significantly increases with a child's weight. These findings establish crucial weight-specific reference values for diagnosing liver conditions in children.

Keywords:

2-dimensional shear wave elastography Liver elasticity Pediatric Sonographic elastography

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Area of Science:

Pediatric Gastroenterology
Medical Imaging
Diagnostic Ultrasound

Background:

Two-dimensional (2-D) shear wave elastography is a noninvasive method for assessing liver stiffness.
Limited data exists on liver stiffness in pediatric populations and its correlation with body weight.

Purpose of the Study:

To establish weight-specific reference liver stiffness values in children without liver disease.
To investigate the association between body weight and liver elasticity in pediatric patients.

Main Methods:

Retrospective single-center study of 171 children undergoing clinically indicated ultrasound.
2-D shear wave elastography performed using Canon Medical Systems Aplio i800 and a450 devices.
Children categorized into ten weight groups to analyze weight-related trends in liver stiffness.

Main Results:

Liver stiffness values demonstrated a significant global trend of increase with rising body weight.
No significant differences were observed between right and left liver lobe stiffness measurements.
The mean normal liver stiffness value across all pediatric participants was 5.3 ± 1.1 kPa.

Conclusions:

Pediatric liver stiffness, assessed via 2-D shear wave elastography, is positively correlated with body weight.
These established weight-specific reference values can aid in differentiating normal from pathological liver stiffness in children.