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Related Concept Videos

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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Disulfidptosis Signature Predicts Immune Microenvironment And Prognosis Of Gastric Cancer.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Disulfidptosis Signature Predicts Immune Microenvironment And Prognosis Of Gastric Cancer.

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Disulfidptosis signature predicts immune microenvironment and prognosis of gastric cancer.

Zitao Liu1, Liang Sun2, Wenjie Zhu1

  • 1Department of General Surgery, The Second Affiliated Hospital of Nanchang University, MinDe Road, Nanchang, Jiangxi, P. R. China.

Biology Direct
|August 15, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Disulfidptosis, a novel cell death pathway, offers new insights into gastric cancer (GC) subtypes. Understanding disulfidptosis signatures aids in personalized treatment and predicting patient prognosis and immune response.

Keywords:
DisulfidptosisGastric cancerImmunotherapyPrognosis

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Area of Science:

  • Oncology
  • Cell Death Mechanisms
  • Molecular Biology

Background:

  • Disulfidptosis is a newly identified cell death mechanism induced by disulfide stress.
  • Gastric cancer (GC) requires novel therapeutic strategies, and understanding its disulfidptosis signature is crucial for personalized treatment.

Purpose of the Study:

  • To identify disulfidptosis subtypes in gastric cancer.
  • To analyze the tumor microenvironment (TME) and prognostic value of disulfidptosis subtypes.
  • To investigate the role of Collagen X (COL10A1) in GC progression.

Main Methods:

  • Consensus clustering was used to identify disulfidptosis subtypes.
  • The Disulfidptosis (Dis) score was developed to quantify subtype and predict prognosis and immune efficacy.
Tumor microenvironment
  • In vitro experiments assessed the impact of COL10A1 on GC cell proliferation, migration, and apoptosis.

    • Main Results:

    • Two distinct disulfidptosis subtypes (Discluster A and B) were identified with differing prognoses, TMEs, and immune profiles.
    • The Dis score effectively predicted GC prognosis and immune response, with low Dis score correlating with better outcomes and immunotherapy sensitivity.
    • Downregulation of COL10A1 inhibited GC cell proliferation and migration while promoting apoptosis.

    Conclusions:

    • The disulfidptosis signature can aid in risk stratification and personalized treatment for gastric cancer patients.
    • These findings provide theoretical support for developing novel anti-tumor strategies targeting disulfidptosis.