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Identification of the novel HLA-DRB3*03:69 allele by next-generation sequencing

Isabella Fantini Molinari1, Anthony Marçal Leão de Oliveira1, Fernanda Pelisson Massi1,2

  • 1Department of Clinical Analysis and Biomedicine (DAB), Postgraduate Program in Biosciences and Physiopathology (PBF), Laboratory of Immunogenetics at the State University of Maringá (LIG-UEM), Maringá, Paraná, Brazil.

HLA
|August 16, 2024
PubMed

Keywords:
Brazilbone marrow transplantationhigh resolutionnew allele

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...