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Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Trityl isocyanide as a general reagent for visible light mediated photoredox-catalyzed cyanations
Irene Quirós1, María Martín1, Carla Pérez-Sánchez1
1Organic Chemistry Department, Faculty of Science, Autonomous University of Madrid (UAM) Madrid 28049 Spain mariola.tortosa@uam.es.
Abstract:
A photoredox catalytic strategy has been developed to enable the functionalization of a variety of commercially available, structurally different radical precursors by the use of a bench-stable isonitrile as an efficient cyanating reagent. Specifically, a radical-based reaction has provided a mild and convenient procedure for the cyanation of primary, secondary and tertiary radicals derived from widely accessible sp3-hybridized carboxylic acids, alcohols and halides under visible light irradiation. The reaction tolerates a variety of functional groups and it represents a complementary method for the cyanation of structurally different scaffolds that show diverse native functionalities, expanding the scope of previously reported methodologies.
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