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Related Experiment Videos

Active and inactive renin in critically ill patients.

R Thatcher, J S Butty, J A Whitworth

    Clinical and Experimental Pharmacology & Physiology
    |November 1, 1985
    PubMed
    Summary

    Critically ill patients show increased active plasma renin concentrations (APRC) and a lower inactive-to-active renin ratio, suggesting renin activation. This pattern was also observed in blood donors, indicating potential renin consumption or preferential active form secretion.

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    Area of Science:

    • Biochemistry
    • Physiology
    • Critical Care Medicine

    Background:

    • Plasma renin concentration (PRC) is crucial for blood pressure regulation.
    • Investigating active (APRC) and inactive (IPRC) renin is key to understanding renin system activation.
    • Shock and tissue damage in critically ill patients may involve altered PRC metabolism.

    Purpose of the Study:

    • To investigate the relationship between APRC and IPRC in critically ill patients.
    • To determine if intravascular renin activation occurs in shock and tissue damage states.
    • To compare PRC profiles in critically ill patients with healthy controls and blood donors.

    Main Methods:

    • Measurement of active and inactive plasma renin concentrations (PRC).
    • Comparison of PRC levels between critically ill patients and age/sex-matched healthy controls.

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  • Analysis of PRC changes in normal volunteers during blood donation.

    • Main Results:

    • Critically ill patients exhibited significantly elevated APRC and a reduced IPRC:APRC ratio compared to controls.
    • IPRC levels were similar between critically ill patients and controls.
    • Blood donors showed a twofold increase in APRC, with a proportionately larger rise than IPRC, leading to a decreased IPRC:APRC ratio.

    Conclusions:

    • Elevated APRC and decreased IPRC:APRC ratio in critically ill patients and blood donors suggest either inactive renin zymogen consumption or preferential active renin secretion.
    • Some critically ill patients with depressed ratios and moderately elevated APRC suggest possible intravascular renin activation.
    • Definitive evidence for consistent intravascular or extravascular renin activation was not established.