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Association between paraoxonase 1 -108C/T polymorphism and coronary heart disease: an updated meta-analysis

Jiadan Liao1, Pengcheng Wang2

  • 1Department of Cardiology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Frontiers in Cardiovascular Medicine
|August 16, 2024
PubMed

Insights

The paraoxonase 1 (PON1) -108T allele is a potential risk factor for coronary heart disease (CHD). This meta-analysis suggests a link between PON1 -108C/T polymorphism and increased CHD susceptibility.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Biomarkers

Background:

  • The association between paraoxonase 1 (PON1) -108C/T polymorphism and coronary heart disease (CHD) susceptibility lacks a clear consensus.
  • Existing studies present conflicting results regarding the role of PON1 genetic variations in CHD risk.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis of existing studies to clarify the relationship between PON1 -108C/T polymorphism and CHD susceptibility.
  • To provide a consolidated view on the genetic contribution of PON1 variations to cardiovascular disease risk.

Main Methods:

  • Systematic search of electronic databases for case-control studies investigating the PON1 -108C/T polymorphism and CHD.
  • Meta-analysis using Stata 12.0 to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
  • Inclusion of 13 case-control studies with 2,979 cases and 2,887 controls.

Main Results:

  • The PON1 -108C/T polymorphism showed a significant association with CHD susceptibility across various genetic models (e.g., T vs. C: OR=1.24, 95% CI 1.07-1.45).
  • Subgroup analyses indicated that race and sample size did not influence the observed results.
  • Bioinformatics analysis suggested that the -108C>T polymorphism impacts PON1 gene expression.

Conclusions:

  • The PON1 -108T allele is identified as a potential low-penetrant risk factor for coronary heart disease (CHD).
  • This meta-analysis supports a genetic link between PON1 -108C/T polymorphism and an increased risk of developing CHD.
Abstract

Keywords:
-108C/TPON1coronary heart diseasemeta-analysisrisk

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