Related Experiment Video

Updated: Jun 16, 2025

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
07:58

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

480

Common protein networks for various drug regimens of major depression are associated with complement and immunity

Seungyeon Lee1, Sora Mun2, Jiyeong Lee3

  • 1Department of Senior Healthcare, Graduate School, Eulji University, Uijeongbu, Republic of Korea.

Journal of Psychopharmacology (Oxford, England)
|August 16, 2024
PubMed
Abstract

Insights

This study compared serum proteins in treated and untreated major depressive disorder (MDD) patients. Key differences involved immune and complement system proteins, offering insights into MDD treatment mechanisms.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Immunology

Background:

  • Major depressive disorder (MDD) exhibits significant heterogeneity in clinical presentation and treatment response.
  • Identifying effective MDD therapeutics is challenging due to inter-individual variability and treatment resistance.
  • Understanding the biological mechanisms underlying MDD heterogeneity and treatment response is crucial.

Purpose of the Study:

  • To explore differentially expressed proteins in the serum of drug-treated (T-MDD) versus untreated (NT-MDD) patients.
  • To identify commonly altered protein networks affected by various antidepressant drug regimens.
  • To gain insights into the biological underpinnings of MDD treatment response.

Main Methods:

  • Serum proteomes of 20 T-MDD patients and 20 NT-MDD patients were analyzed.
  • Liquid chromatography-mass spectrometry (LC-MS) was employed for protein profiling.
  • Differential protein expression and network analysis were conducted.

Main Results:

  • Twelve proteins were significantly differentially expressed between the T-MDD and NT-MDD groups.
  • Commonly altered protein networks across different depression treatments were identified.
  • These networks were primarily associated with the complement system and immune responses.

Conclusions:

  • The study identified common biological changes associated with pharmacological MDD treatments.
  • Findings suggest a role for the immune system and complement pathways in MDD drug response.
  • This research offers a novel perspective on MDD's biological mechanisms, particularly concerning treatment heterogeneity.
Keywords:
Major depressive disordercommon protein networkcomplementimmunitymedication

More Related Videos

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.1K
Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform11:00

Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform

Published on: November 9, 2017

45.0K

Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
2.3K
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K
Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
951
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
117.3K
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
209
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K