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Updated: Jun 16, 2025

A Micropatterning Assay for Measuring Cell Chirality
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Active chiral flows in the separating wall during cell division.

Vijit Ganguly1, Mainak Chatterjee1, Anirban Sain1

  • 1Physics Department, Indian Institute of Technology-Bombay, Powai, Mumbai 400076, India.

The Journal of Chemical Physics
|August 16, 2024
PubMed
Summary
This summary is machine-generated.

Cell division involves chiral material flow in the actomyosin cortex. This study predicts chiral flow signatures in growing intracellular partitions, revealing rotation depends on torque and viscosity.

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Area of Science:

  • Cell biology
  • Biophysics
  • Soft matter physics

Background:

  • Actomyosin cortex material flow during cell division exhibits chirality.
  • This chirality is linked to active chiral torques within the actomyosin cortex.

Purpose of the Study:

  • To investigate the potential signatures of chirality in the growth of intracellular membrane partitions.
  • To predict chiral flow structures within these developing partitions using active gel hydrodynamics.

Main Methods:

  • Application of standard hydrodynamic theory for active gels.
  • Modeling the growth of annular-shaped membrane partitions.

Main Results:

  • Predicted that flows in growing partitions can develop non-zero azimuthal velocity components (rotation) due to chirality.
  • Demonstrated that the direction of rotation is influenced by the active chiral torque, rotational viscosity, and flow coupling parameter.

Conclusions:

  • Chirality in actomyosin cortex material flow can manifest as rotational motion in growing intracellular partitions.
  • The interplay between active chiral torques and material properties dictates the direction of this rotation.