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Two Squamomelanocytic Tumors With Dendritic Melanocytes: Thoughts About Origin
Juliet Suen1, Kiley K Fagan2, Douglas J Grider2,3,4
1Virginia Tech Carilion School of Medicine, Roanoke, VA.
The American Journal of Dermatopathology
|August 16, 2024
Summary
Cutaneous malignant squamomelanocytic tumor (SMT) is a rare skin cancer with two cell types. This study suggests SMT may originate from hair follicles, offering new insights into its development.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Cutaneous malignant squamomelanocytic tumor (SMT) is a rare neoplasm characterized by distinct squamous cell carcinoma and melanocytic components.
- SMT typically presents as a keratotic papule on sun-exposed areas, predominantly affecting middle-aged to elderly White males.
Observation:
- Recent literature shows an increase in SMT case reports, with a 2023 review identifying 37 cases.
- Only three previously reported SMT cases featured spindled or dendritic melanocytic cells; most cases exhibit an epithelioid subtype.
- The origin and pathophysiology of SMT remain poorly understood.
Findings:
- This report details two cases of SMT with dendritic melanocytes specifically centered around hair follicles.
- A novel theory proposes that the dual cell populations in SMT may originate from the hair follicle.
Implications:
- Understanding the follicular origin of SMT could elucidate its pathophysiology.
- This finding may guide future diagnostic and therapeutic strategies for this rare tumor.
- Further research into hair follicle stem cells may reveal insights into SMT development.
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