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Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
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Right ventricular function in Marfan patients remains stable despite multiple cardiac interventions.
Maks Mihalj1,2, Maria Nucera1, Cyril Ferro1
1Department of Cardiac Surgery, University Hospital Bern, University of Bern, Bern, Switzerland.
Summary
In Marfan syndrome patients undergoing cardiac surgery, right ventricular function remains stable long-term. Severe tricuspid regurgitation and the need for tricuspid valve repair are infrequent, even after reoperations.
Area of Science:
- Cardiology
- Cardiovascular Surgery
- Genetics
Background:
- Marfan syndrome commonly presents with mitral valve regurgitation and left ventricular dysfunction.
- Limited data exists on tricuspid valve regurgitation and right ventricular function in Marfan syndrome patients.
Purpose of the Study:
- To investigate long-term changes in right ventricular function.
- To assess tricuspid valve regurgitation progression.
- To determine freedom from tricuspid valve repair in Marfan syndrome patients post-cardiac surgery.
Main Methods:
- Retrospective, single-center analysis of Marfan patients undergoing cardiac surgery between 1995 and 2020.
- Longitudinal echocardiographic analysis of right ventricular function and tricuspid regurgitation.
- Composite endpoint: tricuspid annular plane systolic excursion (TAPSE) ≤16 mm, severe tricuspid regurgitation, or tricuspid repair.
Main Results:
- 135 patients underwent 193 operations; median follow-up was 8 years.
- The composite endpoint occurred in 40 patients, often as a recurrent event.
- Ten-year cumulative incidence for the composite endpoint was 22.0%; new-onset TAPSE ≤16 mm was 9.0%. Tricuspid regurgitation showed annual progression but remained not clinically relevant at 10 years.
- Actuarial 10-year survival was 91.1%.
Conclusions:
- Right ventricular function remains stable in Marfan syndrome patients with a history of cardiac surgery and reoperations.
- The incidence of severe tricuspid regurgitation and the need for tricuspid repair are low.
- Long-term outcomes for right ventricular function and tricuspid valve are favorable in this cohort.
Keywords:
Longitudinal analysisMarfan syndromeRight heart failureRight ventricular functionTricuspid regurgitationMore Related Videos
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