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Related Concept Videos

Ribosome Profiling02:24

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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The organelle-specific signaling sequences direct proteins synthesized in the cytosol to their final destination like ER, mitochondria, peroxisomes, etc. Some of the proteins directed to ER are then trafficked via vesicles to other organelles within the cell or the extracellular environment through the Golgi complex. For example, the rough ER synthesizes soluble proteins for transportation to the lysosomes or secretion out of the cell. It can also synthesize transmembrane proteins that can...
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The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
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Deep Non-Rigid Structure-From-Motion: A Sequence-to-Sequence Translation Perspective.

Hui Deng, Tong Zhang, Yuchao Dai

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    Summary
    This summary is machine-generated.

    This study introduces a novel sequence-to-sequence approach for Non-Rigid Structure-from-Motion (NRSfM) using deep learning. The method reconstructs 3D shapes from 2D sequences by considering temporal dynamics, outperforming existing techniques.

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    Area of Science:

    • Computer Vision
    • Machine Learning
    • 3D Reconstruction

    Background:

    • Traditional Non-Rigid Structure-from-Motion (NRSfM) methods often process 2D frames individually, neglecting the inherent spatial-temporal nature of the problem.
    • Frame-by-frame 3D reconstruction pipelines overlook the sequential data structure crucial for accurate NRSfM.

    Purpose of the Study:

    • To develop a self-supervised, sequence-to-sequence deep learning framework for Non-Rigid Structure-from-Motion (NRSfM).
    • To address the limitations of frame-by-frame reconstruction by treating the 2D keypoint sequence as a whole for 3D reconstruction.

    Main Methods:

    • A sequence-to-sequence translation perspective is employed, utilizing a shape-motion predictor for initial 3D shape and motion estimation.
    • Introduction of a novel Context Layer with multi-head attention (MHA) and temporal encoding to impose self-expressiveness regularity and sequence-level constraints.
    • Self-supervised learning approach reconstructs 3D keypoint sequences from input 2D keypoint sequences.

    Main Results:

    • The proposed framework demonstrates superior performance in 3D reconstruction for Non-Rigid Structure-from-Motion (NRSfM).
    • Experimental validation across diverse datasets including Human3.6M, CMU Mocap, and InterHand confirms the effectiveness of the approach.
    • The method successfully reconstructs 3D sequences by leveraging spatial-temporal information and deep learning constraints.

    Conclusions:

    • The sequence-to-sequence deep learning approach offers a more effective solution for NRSfM compared to traditional frame-by-frame methods.
    • The Context Layer effectively integrates structural characteristics and temporal dynamics for improved 3D reconstruction accuracy.
    • The self-supervised framework provides a robust method for reconstructing non-rigid 3D structures from monocular 2D sequences.