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Related Concept Videos

Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

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The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
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Related Experiment Video

Updated: Jun 16, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
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NCCN Guidelines® Insights: Rectal Cancer, Version 3.2024.

Al B Benson1, Alan P Venook2, Mohamed Adam2

  • 1Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

Journal of the National Comprehensive Cancer Network : JNCCN
|August 16, 2024
PubMed
Summary
This summary is machine-generated.

Optimizing rectal cancer treatment involves balancing curative goals with functional outcomes. Recent updates include new options for early-stage disease and nonoperative management for complete responders.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Rectal cancer treatment requires complex decisions balancing curative intent, functional outcomes (bowel/genitourinary), and quality of life.
  • Distal rectal cancer presents unique challenges in achieving curative therapy with minimal impact on quality of life.
  • Rectal cancer has a higher risk of pelvic recurrence than colon cancer, with locally recurrent disease associated with poor prognosis.

Purpose of the Study:

  • To detail recent updates to the National Comprehensive Cancer Network (NCCN) Guidelines for Rectal Cancer.
  • To highlight advancements in treatment strategies for rectal cancer patients.
  • To inform clinicians on new therapeutic options and management approaches.

Main Methods:

  • Review of recent clinical trial data and guideline revisions for rectal cancer management.
  • Inclusion of endoscopic submucosal dissection for early-stage rectal cancer.
  • Evaluation of total neoadjuvant therapy (TNT) and nonoperative management (watch-and-wait) strategies.

Main Results:

  • Endoscopic submucosal dissection is now an option for select early-stage rectal cancers.
  • Updates to the total neoadjuvant therapy approach are based on recent clinical trial findings.
  • A nonoperative management approach ('watch-and-wait') is recommended for clinical complete responders to neoadjuvant therapy.

Conclusions:

  • A multidisciplinary approach with careful patient selection and sequenced multimodality therapy is recommended for rectal cancer.
  • Recent NCCN guideline updates offer expanded options for early-stage disease and post-neoadjuvant therapy management.
  • These updates aim to improve treatment efficacy while preserving functional outcomes and quality of life for rectal cancer patients.