Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

  1. Home
  3. Research Domains
  5. Chemical Sciences
  7. Macromolecular And Materials Chemistry
  9. Structure And Dynamics Of Materials
  11. Comparative Neuroprotective Potential Of Nanoformulated And Free Resveratrol Against Cuprizone-induced Demyelination In Rats

Comparative Neuroprotective Potential of Nanoformulated and Free Resveratrol Against Cuprizone-Induced Demyelination in Rats

Sara A M El-Sayed1, Ghadha Ibrahim Fouad2, Maha Z Rizk2

  • 1Refractories, Ceramics and Building Materials Department, National Research Centre, 33 El Bohouth St., Dokki, PO Box 12622, Cairo, Egypt. sarali_87@yahoo.com.

Molecular Neurobiology
|August 16, 2024

Related Experiment Videos

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

4.7K
Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.2K
A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats
10:15

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

Published on: November 6, 2019

8.3K

View abstract on PubMed

Summary
This summary is machine-generated.

Resveratrol-loaded iron oxide nanoparticles (IONP-RESV) effectively reduced demyelination and neuroinflammation in a rat model. IONP-RESV demonstrated superior neuroprotection compared to free resveratrol, showing promise for treating neurological diseases like multiple sclerosis.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Pharmacology

Background:

  • Demyelination, a hallmark of multiple sclerosis (MS), causes significant neurological impairment.
  • The cuprizone (CZ) model is widely used to study demyelination induced by oxidative stress and neuroinflammation.
  • Resveratrol (RESV), a polyphenol, exhibits neuroprotective properties.

Purpose of the Study:

  • To investigate the therapeutic efficacy of resveratrol-loaded iron oxide nanoparticles (IONP-RESV) against CZ-induced demyelination and neuroinflammation in a rat model.
  • To compare the neuroprotective effects of IONP-RESV with free RESV.

Main Methods:

  • Induction of demyelination using cuprizone (CZ) in a rat model.
  • Administration of free resveratrol (RESV) and resveratrol-loaded iron oxide nanoparticles (IONP-RESV).
Keywords:
CuprizoneDemyelinationMagnetite nanoparticlesMultiple sclerosis

Related Experiment Videos

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

4.7K
Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.2K
A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats
10:15

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

Published on: November 6, 2019

8.3K
  • Molecular analysis of myelin proteolipid protein (PLP), tumor necrosis factor-α (TNF-α), and S100β expression.
  • Histopathological examination of cerebral cortices.

    • Main Results:

    • CZ exposure led to decreased PLP expression and increased TNF-α and S100β levels, indicating demyelination and neuroinflammation.
    • Both RESV and IONP-RESV treatments reversed CZ-induced alterations.
    • IONP-RESV exhibited enhanced anti-inflammatory activity, with greater downregulation of TNF-α and S100β compared to RESV alone.
    • Histopathology confirmed the neuroprotective effects of both treatments, with IONP-RESV showing superior results.

    Conclusions:

    • RESV-loaded IONPs offer enhanced neuroprotective benefits over free RESV in mitigating demyelination and neuroinflammation.
    • IONP-RESV demonstrates significant pro-remyelinating, anti-inflammatory, and antioxidant properties.
    • IONP-RESV holds promise as a future neurotherapeutic intervention for neurological disorders such as MS.
    Resveratrol