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Ferroptosis: a potential target for acute lung injury
Yuqi Wen1, Yang Liu2, Weihong Liu2
1Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Abstract:
Acute lung injury (ALI) is caused by a variety of intrapulmonary and extrapulmonary factors and is associated with high morbidity and mortality. Oxidative stress is an important part of the pathological mechanism of ALI. Ferroptosis is a mode of programmed cell death distinguished from others and characterized by iron-dependent lipid peroxidation. This article reviews the metabolic regulation of ferroptosis, its role in the pathogenesis of ALI, and the use of ferroptosis as a therapeutic target regarding the pharmacological treatment of ALI.
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