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TMEM252 inhibits epithelial-mesenchymal transition and progression in papillary thyroid carcinoma by regulating

Shuyong Zhang1, Rong Xie1, Liuhuan Wang1

  • 1Department of Thyroid Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Head & Neck
|August 17, 2024
PubMed
Abstract

Insights

Transmembrane protein 252 (TMEM252) suppresses papillary thyroid carcinoma (PTC) progression by inhibiting the Notch pathway. This finding highlights TMEM252 as a potential therapeutic target for PTC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer.
  • Transmembrane protein 252 (TMEM252) has not been previously studied in the context of PTC.
  • This study investigates the role of TMEM252 in PTC pathogenesis.

Purpose of the Study:

  • To elucidate the physiological roles of TMEM252 in PTC.
  • To identify potential regulatory proteins of TMEM252 in PTC.
  • To explore TMEM252 as a therapeutic target for PTC.

Main Methods:

  • Quantitative real-time polymerase chain reaction, western blot, and immunohistochemistry were used to assess TMEM252 expression.
  • Functional assays included CCK-8, EdU, and transwell assays to evaluate proliferation, migration, and invasion.
  • In vivo tumor development assessments were performed.

Main Results:

  • TMEM252 expression was found to be diminished in PTC tissues and cell lines.
  • TMEM252 overexpression suppressed PTC cell proliferation, migration, and invasion by inhibiting the epithelial-mesenchymal transition (EMT) and Notch pathway.
  • TMEM252 overexpression also suppressed tumor growth in vivo.

Conclusions:

  • TMEM252 suppresses PTC progression through modulation of the Notch pathway.
  • TMEM252 demonstrates potential as a therapeutic target for PTC management.
Keywords:
NotchTMEM252papillary thyroid carcinomaprognosisproliferation

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