Related Experiment Video

Updated: May 11, 2026

Murine Cervical Aortic Transplantation Model using a Modified Non-Suture Cuff Technique
00:10

Murine Cervical Aortic Transplantation Model using a Modified Non-Suture Cuff Technique

Published on: November 2, 2019

6.3K

Management of neonatal and infant aortic thrombosis: A single-center case series

Ajibike Lapite1, Mohammad H Abu-Arja1, Hyojeong Han2,3

  • 1Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer and Hematology Center, Houston, Texas, USA.

Pediatric Blood & Cancer
|August 17, 2024
PubMed

Insights

Neonatal aortic thrombosis is a rare but serious condition in infants. Treatment involving thrombolysis or thrombectomy showed positive results with manageable complications, suggesting their consideration in management.

Area of Science:

  • Pediatrics
  • Cardiovascular Medicine
  • Neonatology

Background:

  • Neonatal and infant aortic thrombosis is a rare, life-threatening condition.
  • Premature infants with arterial catheters are particularly at risk.

Purpose of the Study:

  • To describe the institutional experience and management approach for neonatal/infant aortic thrombosis.
  • To evaluate the efficacy and safety of thrombolysis and thrombectomy in this population.

Main Methods:

  • Retrospective review of 11 infants with occlusive or nearly occlusive aortic thrombosis.
  • Analysis of management strategies, including thrombolytic therapy and anticoagulation.
  • Assessment of treatment outcomes and complications.

Main Results:

  • All 11 infants experienced at least partial thrombus resolution.
  • Minor bleeding occurred in two patients receiving thrombolysis.
  • Two major bleeding events were observed in patients receiving anticoagulation alone.

Conclusions:

  • Thrombolysis and thrombectomy should be considered in the management of neonatal/infant aortic thrombosis.
  • These interventions demonstrate efficacy in achieving thrombus resolution.
  • Careful monitoring for bleeding complications is essential during treatment.

Keywords:
anticoagulationarterial thrombusneonatal aortic thrombosisthrombectomythrombolysis

More Related Videos

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn11:27

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

Published on: April 7, 2023

6.2K
Novel and Innovative Hybrid Technique for Type A Aortic Dissection06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

219

Related Concept Videos

Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...