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  11. Association Between Metabolic Syndrome And White Matter Integrity In Young And Mid-age Post-9/11 Adult Veterans.
  1. Home
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  5. Language, Communication And Culture
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  9. Postcolonial Studies
  11. Association Between Metabolic Syndrome And White Matter Integrity In Young And Mid-age Post-9/11 Adult Veterans.

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Association between metabolic syndrome and white matter integrity in young and mid-age post-9/11 adult Veterans.

Emily J Van Etten1,2,3, Aubrey A Knoff1,2,3, Tristan A Colaizzi1

  • 1Translational Research Center for TBI and Stress Disorders (TRACTS), VA Boston Healthcare System, Boston, MA 02130, United States.

Cerebral Cortex (New York, N.Y. : 1991)
|August 17, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Metabolic syndrome is linked to reduced white matter integrity in younger Veterans, particularly in frontal brain regions. Early intervention may prevent age-related cognitive decline.

Keywords:
diffusion tensor imaginghigh-density lipoprotein cholesterolmagnetic resonance imagingmetabolic syndrome

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Area of Science:

  • Neuroscience
  • Public Health
  • Medical Imaging

Background:

  • Metabolic syndrome is linked to brain white matter changes in older adults.
  • Its impact on white matter integrity in younger populations remains understudied.

Purpose of the Study:

  • To investigate metabolic syndrome-related differences in global and regional white matter integrity.
  • To examine these effects in a sample of younger post-9/11 Veterans.

Main Methods:

  • Utilized T1 and diffusion-weighted MRI scans from 537 Veterans.
  • Processed images with FreeSurfer and FSL Diffusion Toolbox.
  • Defined metabolic syndrome by ≥3 factors: increased waist circumference, hypertriglyceridemia, low HDL cholesterol, hypertension, high fasting glucose.
vascular risk
white matter integrity

Main Results:

  • Veterans with metabolic syndrome (n=132) showed significantly lower global fractional anisotropy (FA) than those without (n=405).
  • Low high-density lipoprotein (HDL) cholesterol was the sole metabolic syndrome factor linked to reduced global FA.
  • Metabolic syndrome was associated with decreased FA in frontal white matter regions.

Conclusions:

  • Metabolic syndrome is prevalent in younger Veterans and associated with reduced frontal white matter integrity.
  • Findings suggest early metabolic syndrome intervention may mitigate long-term brain and cognitive effects.