Related Experiment Video

Updated: Jun 16, 2025

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
10:32

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

3.4K

Myopia dominance in preterm infants without and with retinopathy of prematurity: Indian Twin Cities ROP study

Swapnil Thakur1, Seema Kumari1, Vishwa Sanghavi1

  • 1Myopia Research Lab, Prof. Brien Holden Eye Research Centre, Prof. Brien Holden Institute of Optometry and Vision Sciences, LV Prasad Eye Institute, Hyderabad, Telangana, India.

Acta Ophthalmologica
|August 17, 2024
PubMed

Insights

Myopia is more common in preterm infants, especially those with retinopathy of prematurity (ROP). Severe ROP and laser treatment for ROP increase myopia risk, necessitating regular eye exams.

Area of Science:

  • Ophthalmology
  • Neonatal Medicine
  • Pediatric Optometry

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Understanding refractive error progression in infants with ROP is crucial for early intervention.

Purpose of the Study:

  • To analyze refractive errors in premature infants with varying stages of ROP.
  • To compare refractive outcomes between infants with and without ROP.
  • To evaluate the impact of laser treatment on refractive error progression in ROP.

Main Methods:

  • Retrospective analysis of 838 premature infants' data.
  • Categorization based on ROP presence, stage (1-3, aggressive posterior ROP), and laser treatment.
  • Assessment of 1-year refractive error change in a subset of 117 infants.

Main Results:

  • Myopia prevalence was higher in infants with ROP (39.7%) versus no-ROP (19.8%).
  • Myopia increased with ROP severity: Stage 1 (19.7%) to aggressive posterior ROP (59.5%).
  • Laser treatment for ROP doubled myopia risk (54.5% vs. 25.5% in untreated).
  • Significant 1-year myopic shift observed in aggressive posterior ROP and Stage 3 ROP.

Conclusions:

  • Myopia is prevalent in preterm infants, with higher rates in those with ROP.
  • Severe ROP and laser treatment are associated with increased myopia.
  • Meticulous periodic refractive error assessment is essential for preterm infants, especially those with ROP.
Abstract

Keywords:
ROPmyopiaprematurityprogressionrefractive error

More Related Videos

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

2.6K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

2.9K

Related Concept Videos

Focusing of Light in the Eye01:16

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
2.6K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.9K