Related Experiment Video
Updated: Aug 12, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Gliclazide on long-term therapy increases insulin response to glucose of type II diabetics
Abstract:
Twelve type II diabetics were treated with gliclazide, a potent hypoglycaemic sulfonylurea, for 5 months. Plasma immunoreactive insulin (IRI), connecting peptide (C-peptide) and immunoreactive glucagon (IRG) were measured during a 2 h oral glucose tolerance test (OGTT) before and during gliclazide therapy. The OGTT improved in 7 patients. In those patients IRI concentrations were significantly more elevated during than before the treatment period. By contrast, gliclazide treatment did not affect the hepatic extraction of insulin (estimated by the molar ratio of C-peptide to IRI) nor the inappropriate glucagon release commonly observed in this type of patients.
More Related Videos
08:03Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
Published on: June 25, 2017
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
Related Concept Videos
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
Dipeptidyl Peptidase 4 Inhibitors