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Updated: Jun 16, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Systemic sclerosis and environment: an intriguing and still debated association
Gemma Lepri1, Silvia Bellando Randone2, Arianna Damiani2
1Division of Rheumatology, Department of Experimental and Clinical Medicine, AOU Careggi, University of Florence, Italy. lepri.gemma@gmail.com.
Abstract:
Systemic sclerosis (SSc) is characterised by a heterogeneous clinical expression probably reflecting the different genetic background of each patient. Progress has been made in the definition of the principal pathogenetic events of the disease that can be summarised in endothelial damage and dysfunction, inflammation with activation of immune system and fibrosis. The aetiology of the disease still remains to be clarified and probably the first events are attributable to the repeated action of environmental stimuli in genetically predisposed subjects.The aim of the present manuscript is to review the most recent and relevant data regarding the association of SSc with environmental factors.
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