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Related Experiment Videos

Genetically engineered insulin: five years of experience.

J M Brogard, J F Blickle, D Paris-Bockel

    Drugs Under Experimental and Clinical Research
    |January 1, 1985
    PubMed
    Summary

    Genetically engineered insulin, a recombinant DNA product, shows faster absorption and reduced immunogenicity compared to pork insulin. It offers benefits for patients with insulin resistance or allergies.

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    Area of Science:

    • Biotechnology
    • Endocrinology
    • Pharmacology

    Background:

    • Genetically engineered insulin represents a significant advancement as the first recombinant DNA technology product in industrial production and clinical use.
    • Early clinical trials indicate minimal pharmacokinetic differences compared to purified pork insulin, with notable faster subcutaneous absorption for both regular and NPH formulations.

    Purpose of the Study:

    • To evaluate the clinical efficacy and safety of genetically engineered insulin.
    • To compare the pharmacokinetic and immunogenic profiles of genetically engineered insulin with purified pork insulin.
    • To assess the benefits of biosynthetic human insulin in patients with adverse reactions to animal-sourced insulins.

    Main Methods:

    • Clinical trials involving patients with diabetes.
    • Pharmacokinetic studies measuring insulin absorption and glucose-lowering effects.
    • Immunogenicity assessments, including antibody production and cross-reactivity.
    • Evaluation of counterregulatory hormone responses.

    Main Results:

    • Genetically engineered insulin demonstrated identical hypoglycemic potency to purified pork insulin.
    • A faster subcutaneous absorption rate was observed for both regular and NPH forms of genetically engineered insulin.
    • A weaker effect on counterregulatory hormones was reported for genetically engineered insulin.
    • Reduced immunogenicity was a key advantage, particularly beneficial for patients with insulin resistance or allergies, though some cross-reactivity with existing antibodies was noted.

    Conclusions:

    • Genetically engineered insulin offers comparable efficacy to purified pork insulin with improved pharmacokinetic properties and reduced immunogenicity.
    • Its species specificity makes it a valuable therapeutic option for patients experiencing adverse reactions to animal-sourced insulins.
    • While generally well-tolerated, potential cross-reactivity necessitates consideration in specific patient populations.

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