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Hydrogels for Nucleic Acid Drugs Delivery.
Jiaping Liu1, Ziyue Xi1, Chuanyong Fan1
1School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, P. R. China.
Advanced Healthcare Materials
|August 17, 2024
Summary
Hydrogels enhance nucleic acid drug stability and delivery, overcoming key biomedical challenges. This review details hydrogel loading and release strategies for improved therapeutic applications.
Area of Science:
- Biomedicine
- Drug Delivery Systems
- Materials Science
Background:
- Nucleic acid drugs show therapeutic promise but face stability and targeted delivery issues.
- Hydrogels offer a solution to improve nucleic acid drug stability and control release.
- Addressing these limitations is crucial for advancing nucleic acid-based therapies.
Purpose of the Study:
- To review strategies for loading nucleic acid drugs into hydrogels.
- To classify the binding mechanisms involved in hydrogel drug loading.
- To summarize various hydrogel-based drug release mechanisms and future applications.
Main Methods:
- Literature review of hydrogel-based nucleic acid drug delivery systems.
- Classification of loading strategies: electrostatic, hydrogen bond, hydrophobic, covalent, and indirect binding.
- Categorization of release mechanisms: photostimulation, enzyme, pH, and temperature responsiveness.
Main Results:
- Hydrogels effectively improve nucleic acid drug stability and controlled release.
- Diverse binding mechanisms enable versatile hydrogel formulation.
- Stimuli-responsive hydrogels offer tunable drug release profiles.
Conclusions:
- Hydrogels are a promising platform for enhancing nucleic acid drug delivery.
- Further research into hydrogel applications can optimize therapeutic outcomes.
- Future directions include refining delivery systems and exploring novel applications.
