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Calcium-channel blockers and systemic hypertension.

W H Frishman, S Charlap, S Ocken

    Journal of Clinical Hypertension
    |June 1, 1985
    PubMed
    Summary

    Calcium-channel blockers reduce calcium flow in tissues, causing vasodilation. Clinical trials indicate these blockers may effectively treat systemic hypertension by lowering vascular tone.

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    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine

    Background:

    • Calcium ions play a critical role in the electromechanical coupling of excitable tissues.
    • Increased vascular tone in hypertension is potentially linked to calcium's involvement.
    • Peripheral vasodilation is a known effect of blocking calcium-mediated pathways.

    Purpose of the Study:

    • To investigate the therapeutic potential of calcium-channel blockers for managing systemic hypertension.
    • To evaluate the efficacy of calcium-channel blockers as vasodilators in hypertensive patients.

    Main Methods:

    • Review of clinical trial data on calcium-channel blockers.
    • Analysis of the mechanism of action of calcium-channel blockers on transmembrane calcium flux.
    • Assessment of the vasodilatory effects and impact on systemic hypertension.

    Main Results:

    • Calcium-channel blockers selectively inhibit calcium influx in excitable tissues.
    • The agents induce peripheral vasodilation by blocking calcium-mediated electromechanical coupling.
    • Clinical trials demonstrate a significant role for these blockers in treating hypertension.

    Conclusions:

    • Calcium-channel blockers are effective vasodilators due to their selective inhibition of calcium flux.
    • These agents show promise as a valuable therapeutic option for systemic hypertension management.

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