Calpain: The regulatory point of cardiovascular and cerebrovascular diseases

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Xiaolu Zhang1, Yujia Zheng1, Ziyu Wang1

  • 1Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 17, 2024
PubMed

Insights

Calpain dysregulation contributes to cardiovascular and cerebrovascular diseases through lipid metabolism, inflammation, and apoptosis. Further research into Calpain inhibition offers a promising therapeutic avenue for these conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathology

Background:

  • Calpains are calcium-dependent cysteine proteases involved in cellular signaling.
  • Aberrant calpain activation can lead to non-specific protein cleavage and cellular damage.
  • The calpain system's role in cardiovascular and cerebrovascular diseases is increasingly recognized.

Purpose of the Study:

  • To review the literature on calpain's involvement in cardiovascular and cerebrovascular diseases from 2010-2023.
  • To elucidate the pathological mechanisms linking calpain dysregulation to these diseases.
  • To explore the therapeutic potential of calpain inhibition.

Main Methods:

  • Comprehensive literature review of studies published between 2010 and 2023.
  • Analysis of research focusing on calpain's role in cardiovascular and cerebrovascular pathologies.
  • Synthesis of findings regarding calpain's association with lipid metabolism, inflammation, apoptosis, and excitotoxicity.

Main Results:

  • 121 references were identified discussing calpain in cardiovascular and cerebrovascular diseases.
  • Calpain dysregulation is linked to lipid metabolism disorders, inflammation, apoptosis, and excitotoxicity.
  • The precise mechanisms of calpain's involvement in these diseases require further investigation.

Conclusions:

  • Calpain plays a significant role in the pathogenesis of cardiovascular and cerebrovascular diseases.
  • Understanding calpain's complex mechanisms is crucial for therapeutic development.
  • Calpain inhibition presents a compelling future research direction for treating these conditions.
Keywords:
AtherosclerosisCalpainCardiovascular diseasesCerebrovascular diseasesTreatment strategies

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