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Brain structural-functional coupling mechanism in mild subcortical stroke and its relationship with cognition
Chang Liu1, Lijun Zuo2, Zixiao Li2
1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Brain Research
|August 17, 2024
Summary
Subcortical stroke impairs brain structural-functional coupling (SC-FC coupling), leading to cognitive deficits. Recovery shows increased SC-FC coupling in the frontal lobe, suggesting a compensatory mechanism for cognitive improvement.
Area of Science:
- Neuroscience
- Neurology
- Cognitive Science
Background:
- Stroke, particularly affecting the basal ganglia, causes significant brain restructuring.
- Understanding the impact on structural-functional coupling (SC-FC coupling) and cognitive function is crucial for subcortical stroke patients.
Purpose of the Study:
- To investigate alterations in SC-FC coupling in subcortical basal ganglia infarction patients.
- To determine the relationship between SC-FC coupling changes and cognitive function.
Main Methods:
- 40 mild stroke patients (basal ganglia infarcts) and 29 healthy controls (HC) underwent neuroimaging and neuropsychological testing.
- Patients were categorized into post-stroke cognitive impairment (PSCI) and stroke with no cognitive impairment (NPSCI) groups.
- Follow-up assessments were conducted after three months to track changes in SC-FC coupling.
Main Results:
- PSCI patients showed significantly reduced SC-FC coupling compared to HC and NPSCI groups.
- After three months, SC-FC coupling increased in the frontal lobe (precentral gyrus, paracentral lobule).
- Reduced SC-FC coupling in specific regions correlated with cognitive decline (MoCA, memory, visual motor speed).
Conclusions:
- Subcortical stroke leads to decreased frontal lobe SC-FC coupling, associated with cognitive impairment.
- Increased frontal lobe SC-FC coupling during recovery suggests a compensatory mechanism for cognitive function post-stroke.
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