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Updated: Jun 16, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

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Advances in psoriasis research: From pathogenesis to therapeutics

Dineshwar Sugumaran1, Audrey Chee Hui Yong2, Johnson Stanslas1

  • 1Pharmacotherapeutic Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Life Sciences
|August 17, 2024
PubMed

Insights

Psoriasis, a chronic inflammatory skin disease, involves complex immune pathways. This review highlights current research on its pathogenesis, signaling pathways, and novel therapeutic strategies for improved patient management.

Area of Science:

  • Dermatology and Immunology
  • Molecular Biology
  • Pharmacology

Background:

  • Psoriasis affects 2-3% of the global population as a chronic inflammatory skin condition.
  • Its pathogenesis is multifactorial, involving immune dysregulation, hyperproliferation, angiogenesis, and genetic/environmental factors.

Purpose of the Study:

  • To review the current understanding of psoriasis pathogenesis.
  • To highlight advancements in therapeutic agents and drug delivery strategies.
  • To identify future research opportunities for personalized interventions.

Main Methods:

  • Comprehensive literature review of psoriasis pathogenesis.
  • Analysis of signaling pathways (NF-κB, JAK-STAT, S1P, PDE-4, A3AR) involved in psoriasis.
  • Examination of preclinical models and technological advancements in psoriasis research.

Main Results:

  • Detailed overview of key signaling pathways implicated in psoriasis.
  • Discussion of approved and investigational molecules targeting these pathways.
  • Exploration of recent breakthroughs in therapeutic and drug delivery approaches.

Conclusions:

  • An extensive understanding of psoriasis pathogenesis, signaling pathways, and therapeutic agents is crucial for developing efficient treatments.
  • Technological advancements and novel drug delivery strategies offer opportunities for improved psoriasis management.
  • This review provides a foundation for future research into personalized psoriasis interventions.
Keywords:
BiologicsNF-κBPreclinical modelsPsoriasisSignalling pathwaysTherapeutic approaches

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