Oxidative phosphorylation and fatty acid oxidation in slow-aging mice
Ahmed M Elmansi1, Richard A Miller1
1Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA; University of Michigan Geriatrics Center, Ann Arbor, MI, USA.
Abstract:
Oxidative metabolism declines with aging in humans leading to multiple metabolic ailments and subsequent inflammation. In mice, there is evidence of age-related suppression of fatty acid oxidation and oxidative phosphorylation in the liver, heart, and muscles. Many interventions that extend healthy lifespan of mice have been developed, including genetic, pharmacological, and dietary interventions. In this article, we review the literature on oxidative metabolism changes in response to those interventions. We also discuss the molecular pathways that mediate those changes, and their potential as targets for future longevity interventions.
Insights
Aging reduces oxidative metabolism, impacting health and causing inflammation. This review explores interventions that boost metabolism and extend lifespan by targeting molecular pathways.
Area of Science:
- Gerontology and metabolic research.
- Focus on cellular energy production and aging processes.
Background:
- Oxidative metabolism and its decline with aging are linked to metabolic diseases and inflammation.
- Age-related suppression of fatty acid oxidation and oxidative phosphorylation observed in key tissues like liver, heart, and muscles.
Purpose of the Study:
- To review existing literature on how various interventions affect oxidative metabolism during aging.
- To discuss molecular pathways involved in these metabolic changes.
- To identify potential targets for future longevity interventions.
Main Methods:
- Literature review of studies on genetic, pharmacological, and dietary interventions in aging mice.
- Analysis of molecular pathways mediating metabolic changes.
Main Results:
- Interventions can modulate age-related decline in oxidative metabolism.
- Specific molecular pathways are identified as key mediators of these changes.
Conclusions:
- Understanding the interplay between aging, oxidative metabolism, and interventions is crucial for developing strategies to promote healthy lifespan.
- Targeting these molecular pathways holds promise for future longevity interventions.
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