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Essential oils loaded carboxymethylated Cassia fistula gum-based novel hydrogel films for wound healing

  • 0Department of Applied Chemistry, Delhi Technological University, Delhi, India.
International Journal of Biological Macromolecules +

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August 17, 2024

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August 17, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

A novel carboxymethylated Cassia fistula gum and citric acid hydrogel film loaded with essential oils demonstrated 99% wound healing in rats within 14 days. This biocompatible film offers antioxidant and antimicrobial properties for effective wound management.

Area Of Science

  • Biomaterials Science
  • Polymer Chemistry
  • Wound Healing Research

Background

  • Developing effective wound dressings is crucial for patient recovery.
  • Natural polymers offer biocompatible and biodegradable alternatives for wound healing applications.
  • Cassia fistula gum presents a promising source for biomaterial development.

Purpose Of The Study

  • To develop and characterize a novel carboxymethylated Cassia fistula gum and citric acid based hydrogel film (CCFG-CA).
  • To incorporate essential oils (rosemary, turmeric, thuja) into the hydrogel film to enhance its therapeutic properties.
  • To evaluate the in vitro and in vivo efficacy of the essential oil-loaded hydrogel film (CCFG-CA-EO) for wound healing.

Main Methods

  • Solvent casting method was employed for film synthesis.
  • Morphological, thermal, and structural characterization using FESEM, TGA, XRD, and FTIR.
  • In vitro assays (MTT, disk diffusion, DPPH) and in vivo wound healing studies on wistar rats.

Main Results

  • The CCFG-CA-EO film exhibited excellent biocompatibility, antioxidant, and antimicrobial activities.
  • In vivo studies showed 99% wound healing and re-epithelialization within 14 days.
  • The film demonstrated biodegradability within 15 days, with significant protein adsorption and favorable contact angle.

Conclusions

  • The developed CCFG-CA-EO hydrogel film is a promising candidate for effective wound healing applications.
  • The combination of Cassia fistula gum, citric acid, and essential oils provides synergistic therapeutic benefits.
  • The material's properties support its potential as an advanced wound dressing.

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