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Updated: Jun 16, 2025

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Parabiosis in Mice: A Detailed Protocol
Published on: October 6, 2013
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Aging insights from heterochronic parabiosis models
Francisco Alejandro Lagunas-Rangel1
1Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. francisco.lagunas@neuro.uu.se.
Npj Aging
|August 17, 2024
Abstract:
Heterochronic parabiosis consists of surgically connecting the circulatory systems of a young and an old animal. This technique serves as a model to study circulating factors that accelerate aging in young organisms exposed to old blood or induce rejuvenation in old organisms exposed to young blood. Despite the promising results, the exact cellular and molecular mechanisms remain unclear, so this study aims to explore and elucidate them in more detail.

