Causal Associations of Cognitive Reserve and Hierarchical Aging-Related Outcomes: A Two-Sample Mendelian
Yanyan Li1, Zhenhuang Zhuang2, Huaxin Si1
1Department of Basic Nursing, School of Nursing, Peking University, Beijing, China.
Purpose:
Two-sample Mendelian randomization methods were used to explore the causal effects of cognitive reserve proxies, such as educational attainment, occupational attainment, and physical activity (PA), on biological (leukocyte telomere length), phenotypic (sarcopenia-related features), and functional (frailty index and cognitive performance) aging levels.
Results:
Educational attainment had a potential protective effect on the telomere length (β = 0.10, 95% CI: 0.08-0.11), sarcopenia-related features (β = 0.04-0.24, 95% CI: 0.02-0.27), frailty risk (β = -0.31, 95% CI: -0.33 to -0.28), cognitive performance (β = 0.77, 95% CI: 0.75-0.80). Occupational attainment was causally related with sarcopenia-related features (β = 0.07-0.10, 95% CI: 0.05-0.14), and cognitive performance (β = 0.30, 95% CI: 0.24-0.36). Device-measured PA was potentially associated with one sarcopenia-related feature (β = 0.14, 95% CI: 0.03-0.25).
Conclusions:
Our findings support the potential causality of educational attainment on biological, phenotypic, and functional aging outcomes, of occupational attainment on phenotypic and functional aging-related outcomes, and of PA on phenotypic aging-related outcomes.
More Related Videos
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
08:43Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
Related Concept Videos
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cognitive Development During Adulthood
Biological Influences on Intelligence
Causality in Epidemiology
Language and Cognition
Revisionist Views of Adolescent and Adult Cognition
