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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Role of osteokines in atherosclerosis

Yi-Fan Liu1, Yuan Tian2, Xiao-Fang Chen1

  • 1Institute of Translational Medicine, School of Basic Medical, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Cell Biochemistry and Function
|August 18, 2024
PubMed

Insights

Bone-derived factors called osteokines play a role in atherosclerosis. This review examines osteokines like osteocalcin and their link to cardiovascular disease, exploring exercise effects.

Area of Science:

  • Bone Biology and Cardiovascular Disease
  • Endocrinology and Metabolism

Background:

  • Heart, skeletal, and smooth muscles share embryonic origins with bone.
  • Bone health is regulated by osteocytes, osteoblasts, and osteoclasts secreting osteokines.
  • Osteokines are increasingly implicated in the development of atherosclerotic vascular disease.

Purpose of the Study:

  • To comprehensively review the evidence for osteokines' role in atherosclerosis.
  • To discuss specific osteokines like osteocalcin, osteopontin, osteoprotegerin, and FGF23 in atherosclerosis.
  • To explore the impact of exercise on bone-derived regulators in cardiovascular disease.

Main Methods:

  • Literature review of studies on osteokines and atherosclerosis.
  • Analysis of conserved signaling pathways between bone and cardiovascular tissues.
  • Examination of the metabolic effects of exercise on bone-derived factors.

Main Results:

  • Osteokines are involved in the regulation of atherosclerotic vascular disease.
  • Key osteokines such as osteocalcin and osteopontin have demonstrated roles in atherosclerosis.
  • Exercise can modulate key bone-derived regulators involved in cardiovascular health.

Conclusions:

  • Understanding osteokine involvement in atherosclerosis is crucial for therapeutic development.
  • Targeted strategies against atherosclerosis can be developed by elucidating osteokine functions.
  • Further research into osteocalcin's contribution to atherosclerosis may yield novel treatment approaches.

Keywords:
atherosclerosiscalcificationfibroblast growth factor 23osteocalcinosteopontinosteoprotegerin

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