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Pirprofen in postoperative course following cataract extraction: a controlled trial
Drugs Under Experimental and Clinical Research
|January 1, 1985
Summary
Pirprofen and indomethacin effectively reduced inflammation and pain after cataract surgery, outperforming placebo. Both drugs were well-tolerated with no significant adverse laboratory effects observed.
Area of Science:
- Ophthalmology
- Pharmacology
- Clinical Trials
Background:
- Post-operative inflammation and pain are common complications following cataract extraction.
- Cyclo-oxygenase (COX) inhibitors are frequently used to manage ocular inflammation.
Purpose of the Study:
- To evaluate the efficacy and safety of pirprofen, a new cyclo-oxygenase inhibitor, in managing post-operative inflammation and pain.
- To compare pirprofen with indomethacin and placebo in patients undergoing cataract surgery.
Main Methods:
- A double-blind, between-patient clinical trial involving 56 patients undergoing cataract extraction.
- Patients received pirprofen (800 mg/day), indomethacin (100 mg/day), or placebo.
- Treatment commenced 48 hours pre-operatively and continued for eight days, with assessments on days 1, 3, and 6.
Main Results:
- Both pirprofen and indomethacin demonstrated significant anti-inflammatory action, superior to placebo.
- Objective signs of inflammation and pain were markedly reduced in the active treatment groups.
- No significant adverse effects or laboratory parameter changes were reported for either active drug.
Conclusions:
- Pirprofen is an effective anti-inflammatory agent for managing post-operative inflammation and pain after cataract surgery.
- Pirprofen exhibits comparable efficacy to indomethacin in this context.
- The safety profile of pirprofen in this study was favorable.