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Published on: September 30, 2020
Characteristics Associated with Long-Term Outcomes in Severe COVID-19 Patients after a Post-Acute Care
Joao Gabriel Rosa Ramos1, Larrie Rabelo Laporte2, Flaviane Ribeiro de Souza2
1Clínica Florence, Salvador, Brazil; Faculdade de Medicina, Universidade Federal da Bahia, Brazil.
Insights
Severe COVID-19 patients showed significant functional recovery in post-acute care facilities (PACF) and over 180 days. Baseline factors predict long-term outcomes for these critical illness survivors.
Area of Science:
- Medical Rehabilitation
- Infectious Diseases
- Critical Care Medicine
Background:
- Severe COVID-19 survivors often require intensive post-acute care for functional recovery.
- Understanding long-term outcomes is crucial for managing patients after severe illness.
Purpose of the Study:
- To identify characteristics associated with long-term outcomes in severe COVID-19 patients admitted to a post-acute care facility (PACF).
Main Methods:
- Prospective cohort study of 186 severe COVID-19 patients admitted to a PACF.
- Functional outcomes assessed using the modified Barthel index over 180 days post-discharge.
- Multivariate binary logistic regression analyzed patient characteristics and outcomes.
Main Results:
- Patients experienced significant functional improvements (Barthel index) from admission to 180-day follow-up (P < .001).
- 180-day mortality was 17.2%.
- Baseline functional status, comorbidities, and admission functional status predicted poor 180-day outcomes.
Conclusions:
- Severe COVID-19 patients demonstrate substantial functional gains in PACF and long-term.
- Findings aid in prognostication and management strategies for post-acute COVID-19 care.
- Identifying predictors of poor outcomes can guide targeted interventions.
Objectives:
To describe characteristics associated with long-term outcomes in severe COVID-19 patients admitted to a post-acute care facility (PACF).
Design:
Prospective cohort.
Setting And Participants:
Consecutive severe COVID-19 admitted to a PACF from April 2020 to August 2021.
Methods:
Patients were followed for 180 days after discharge. Functional outcomes were measured by the modified Barthel index and further stratified into good outcome (for those independent, mildly dependent, or moderately dependent) and into bad outcome (for those severely dependent, completely dependent, or dead). Multivariate binary logistic regression was performed to evaluate between patients' characteristics and long-term outcomes.
Results:
A total of 186 patients admitted from 17 different acute hospitals were included. Median age was 67 years, 88% of patients were previously independent, 95% were admitted to the ICU, and 85% were mechanically ventilated during the acute hospitalization. Median (interquartile range) Barthel indexes at admission, discharge, and 180-day follow-up were 9 (1-23), 81 (45-92), and 100 (98-100) (P < .001), respectively. In addition, 180-day mortality was 17.2%. Baseline functional status, comorbidities, and functional status at admission to the PACF were associated with bad outcome at 180-day follow-up, after multivariate binary logistic regression.
Conclusions And Implications:
Patients with severe COVID-19 admitted to a PACF had substantial functional improvements at PACF discharge and during 180-day follow-up. These findings may help prognosticate and manage post-acute severe COVID-19 patients.
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