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Related Experiment Video

Updated: Jun 16, 2025

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Social vulnerability and prenatal diagnosis.

Insaf Kouba1,2,3, Jaclyn Del Pozzo1,2,3, Alejandro Alvarez1,4

  • 1Northwell, New Hyde Park, NY, USA.

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|August 19, 2024
PubMed
Summary

Neighborhood social vulnerability does not impact prenatal diagnosis rates. This study found no association between the social vulnerability index (SVI) and prenatal diagnostic procedures in pregnant patients. Further research may be needed in diverse populations.

Keywords:
amniocentesischorionic villi samplinggenetic counselingprenatal diagnosissocial vulnerability index

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Area of Science:

  • Reproductive Health
  • Public Health
  • Genetic Counseling

Background:

  • Limited data exist on neighborhood risk factors influencing prenatal diagnosis rates.
  • The Social Vulnerability Index (SVI) quantifies cumulative environmental stressors impacting health.
  • Understanding SVI's role is crucial for equitable prenatal care access.

Purpose of the Study:

  • To determine the relationship between the Social Vulnerability Index (SVI) and prenatal diagnosis.
  • To analyze SVI's impact on pregnant patients undergoing genetic counseling.
  • To assess neighborhood-level socioeconomic factors in prenatal diagnostic decision-making.

Main Methods:

  • Retrospective cohort study of 5,935 pregnant patients receiving genetic counseling in New York (2019-2022).
  • Linking patient residence to census tract-based Social Vulnerability Index (SVI) scores.
  • Utilizing multivariable logistic regression to analyze the primary outcome: prenatal diagnosis (yes/no).

Main Results:

  • No statistically significant association was observed between SVI and prenatal diagnosis.
  • Factors associated with increased prenatal diagnosis included English speaking, genetic disorder carrier status, increased NT, abnormal NIPS, and fetal structural anomalies.
  • No significant differences in diagnosis rates were found based on race, ethnicity, insurance, or marital status.

Conclusions:

  • The Social Vulnerability Index (SVI) does not appear to influence the rate of prenatal diagnosis in this New York population.
  • Findings suggest that other factors, beyond neighborhood social vulnerability, are more strongly associated with prenatal diagnostic procedures.
  • Further investigation in different geographic regions and diverse populations is warranted to confirm these findings.