Related Experiment Video
Updated: Jun 14, 2026
07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
18.8K
Visual morbidity in macroprolactinoma: A retrospective cohort study
Yaron Rudman1,2, Hadar Duskin-Bitan1,2, Hiba Masri-Iraqi1,2
1Institute of Endocrinology, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel.
Clinical Endocrinology
|August 19, 2024
Summary
Macroprolactinoma can cause visual field damage, but treatment offers significant recovery. Smaller tumors and lower prolactin levels predict better visual outcomes in patients with macroprolactinoma.
Area of Science:
- Endocrinology
- Neuro-ophthalmology
- Oncology
Background:
- Macroprolactinomas, a type of pituitary tumor, frequently cause visual field damage, posing a significant clinical challenge.
- Understanding the factors influencing visual recovery is crucial for optimizing patient management.
Purpose of the Study:
- To investigate the visual morbidity associated with macroprolactinoma.
- To evaluate the outcomes of medical and surgical treatments on visual function.
- To identify predictors of visual recovery in patients with macroprolactinoma.
Main Methods:
- Retrospective review of 150 patients with macroprolactinoma.
- Data collected included clinical presentation, MRI, laboratory tests, and neuro-ophthalmologic examinations.
- Primary outcome was complete visual field recovery; predictors were analyzed.
Main Results:
- 26.7% of patients presented with visual field defects at diagnosis.
- Complete visual recovery was achieved in 61.5% of available follow-up tests.
- Predictors of recovery included smaller tumor size, lower prolactin levels, and better baseline visual acuity.
Conclusions:
- A significant proportion of macroprolactinoma patients experience visual field defects, but treatment can lead to substantial recovery.
- Early detection and treatment, considering tumor size and prolactin levels, are key for favorable visual outcomes.
More Related Videos
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:26Cushing Syndrome I: Introduction
Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
01:19Cushing Syndrome II: Pathophysiology
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...