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Infectious Disease Prophylaxis During and After Immunosuppressive Therapy
Lorne Schweitzer1,2,3, Benjamin A Miko1,2, Marcus R Pereira1,2
1Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Kidney International Reports
|August 19, 2024
Summary
Nephrologists can reduce infection risks in patients with immune-mediated renal diseases by understanding how immunosuppressants affect the immune system. This review aids in preventing opportunistic infections in non-kidney transplant recipients.
Area of Science:
- Nephrology
- Immunology
- Infectious Diseases
Background:
- Immune-mediated renal diseases result from immune system dysregulation.
- These conditions increase susceptibility to infections.
- Immunosuppressant therapies, while crucial, further elevate infection risks.
Purpose of the Study:
- To review infections associated with immunosuppressants used in immune-mediated renal diseases.
- To guide nephrologists in preventing and recognizing opportunistic infections.
- To focus on non-kidney transplant recipients.
Main Methods:
- Literature review of infections linked to common immunosuppressive agents.
- Analysis of immune system components targeted by these drugs.
- Identification of preventive strategies for infectious complications.
Main Results:
- Specific infections correlate with distinct immunosuppressive mechanisms.
- Understanding drug action aids in risk anticipation.
- Proactive interventions can mitigate infectious risks.
Conclusions:
- Targeted understanding of immunosuppressant-infection links is vital.
- Nephrologists can optimize patient care by anticipating and managing infectious risks.
- Effective prevention strategies are crucial for patients with immune-mediated renal diseases.
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