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Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

63
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
63

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Prospective Study on Kidney Dysfunction Markers and Risk for Mortality among South Asians.

Ram Jagannathan1, Shuchi Anand2,3,4, Dimple Kondal2,3

  • 1Emory Global Diabetes Research Center, Woodruff Health Sciences Center and Emory University, Atlanta, Georgia, USA.

Kidney International Reports
|August 19, 2024
PubMed
Summary

Impaired kidney function markers, including albuminuria and reduced eGFR, significantly increase mortality risk in South Asians. Early screening and interventions for albuminuria are crucial for this population.

Keywords:
South Asiansalbuminuriaglomerular filtration ratemortality

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Area of Science:

  • Nephrology
  • Cardiovascular Epidemiology
  • Public Health

Background:

  • Associations between kidney function markers and adverse outcomes in South Asians are understudied.
  • Existing data primarily comes from North American or European cohorts, potentially differing from South Asian populations.

Purpose of the Study:

  • To examine the association between baseline urine albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) with all-cause mortality in South Asians.
  • To calculate the population attributable fraction (PAF) for these markers in relation to mortality.

Main Methods:

  • Prospective analysis of 9797 participants from a South Asian cardiometabolic study.
  • Cox proportional hazards regression was used to assess the association between UACR and eGFR with mortality, adjusting for key risk factors.

Main Results:

  • Higher UACR and lower eGFR were significantly associated with increased all-cause mortality risk.
  • The population attributable fraction for mortality was 24.4% for UACR ≥ 30 mg/g and 13.4% for eGFR < 45 ml/min per 1.73 m².

Conclusions:

  • Single-time point assessment of elevated UACR or reduced eGFR indicates higher mortality risk in urban South Asians.
  • Albuminuria is common and linked to faster GFR decline, warranting screening and targeted reduction efforts.