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Updated: Jun 16, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
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Beyond Bronchopulmonary Dysplasia: A Comprehensive Review of Chronic Lung Diseases in Neonates

Khaled El-Atawi1, Muzafar Gani Abdul Wahab2, Jubara Alallah3,4

  • 1Pediatrics, Latifa Women and Children Hospital, Dubai, ARE.

Cureus
|August 19, 2024
PubMed

Insights

Chronic lung diseases (CLDs) in neonates present complex challenges. This review covers their causes, management, and future directions, emphasizing personalized medicine and supportive care for improved outcomes.

Area of Science:

  • Neonatology
  • Pulmonology
  • Genetics

Background:

  • Neonatal chronic lung diseases (CLDs) are complex, leading to significant morbidity and mortality.
  • Understanding the etiology and pathophysiology is crucial for effective management.

Purpose of the Study:

  • To review the etiology, pathophysiology, clinical presentation, diagnostic criteria, and management of neonatal CLDs.
  • To highlight advancements in understanding and evolving treatment strategies.

Main Methods:

  • Comprehensive literature review of neonatal pulmonary diseases.
  • Analysis of current and emerging therapeutic approaches, including gene therapy, stem cells, and personalized medicine.

Main Results:

  • CLDs require a multidisciplinary approach with supportive care.
  • Personalized medicine, leveraging genomics, offers tailored therapeutic strategies.
  • Advancements include gene therapy and stem cell treatments.

Conclusions:

  • A comprehensive, patient-centered approach is essential for improving care and outcomes in neonates with CLDs.
  • Further multicentric, longitudinal studies are needed to refine preventative strategies and understand long-term outcomes.
  • Continued research into targeted treatment modalities and improved diagnostics is vital.

Keywords:
bronchopulmonary dysplasia (bpd)chronic lung diseases in neonatescongenital diaphragmatic hernia (cdh)neonatespulmonary hypoplasia

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